A B O U T   M E

My research focuses on mechanisms of neurodevelopmental and diseases related to the dysfunctional development using the zebrafish model.  Currently, I am applying cellular, molecular, and behavioral strategies to study the hypoxia effects on the brain connectivity (e.g., axon pathfinding and synaptic connectivity) and diseases of development, particularly prematurity and cerebral palsy. 
I am also teaching General Biology Lecture (BIOL 141), Genetics Lecture (BIOL 260), Neuroscience Research Literature Seminar (NEUR 111), and Neuroscience Research and Methods (NEURO 330).

RESEARCH INTERESTS

Hypoxia injury to the development of CNS connectivity and Neurodevelopmental outcomes.
          - Axon pathfinding
          - Synaptic connectivity

- Hypoxic injury to the developing human brain from prematurity by an inadequate supply of oxygen to the nervous system increases the risk of permanent behavioral and intellectual deficits (Bass et al., 2004; Barrett et al., 2007). However, the precise mechanisms by which hypoxia disrupts brain connectivity in the developing vertebrate brain are still unknown.

  •           - Cerebral Palsy
  •           - Autism Spectrum Disorders
  •           - Bipolar Disorders
  •           - Epilepsy
  •           - Depression
  •           - Intellectual Disabilities

V I E W   M O R E

JONG-HYUN SON (Ph.D.)
EDUCATION:         
2013 - 2017     Postdoctoral Research Associate, Dept. of Pediatrics, School of Medicine, Univ. of Utah, Salt Lake City, UT
2009-2013       Postdoctoral fellow, Dept. of Pharmacology and Toxicology, Univ. of Utah, Salt Lake City, UT
2002-2009       Ph.D., Neuroscience and Experimental Therapeutics, Texas A&M University of the Health Sciences, College Station, TX
1999-2001       M.S., Biological Science, Western Illinois University, Macomb, IL
1989-1993       B.S., Animal Science, Dankook University, Korea
TEACHING:
Neuroscience research literature, Spring 2018        Neuroscience Research and Methods, Spring 2018
Undergraduate Research in Neuro, Spring 2018     Faculty-student research, Spring 2018
Special Topics, Spring 2018
General Biology, Fall 2017                                        Genetics, Fall 2017

PUBLICATIONS:
1. T.M. Furlong, Lee S. Leavitt, Kristin A. Keefe, Jong-Hyun Son (2016) Methamphetamine, d-amphetamine, and p-chloroamphetamine induced neurotoxicity differentially effect impulsive responding on the stop-signal task in rats. Neurotoxicity ResearchFeb 1-14, doi:10.1007/s12640-016-9605-9
2. Jong-Hyun Son, Matthew D. Keefe, T. Stevenson, J. Barrios, S. Anjewierden, J. Newton, A. Douglass, J.L. Bonkowsky (2016) Transgenic FingRs for live mapping of synaptic dynamics in genetically-defined neurons. Scientific reports6, 18734, doi:10.1038/srep18734 

3. B. Milash, T. Stevenson, Jong-Hyun Son, T. Dahl, J.L. Bonkowsky (2015) Temporal dysynchrony in brain connectivity gene expression following hypoxia. BMC Genomics May 4;17:334. doi: 10.1186/s12864-016-2638-x.
4. L. Xing, Jong-Hyun Son, T. Stevenson, C. Lillesaar, L. Bally-Cuif, J.L. Bonkowsky (2015) A serotonin circuit acts as an environmental sensor to mediate midline axon crossing through EphrinB2. J Neurosci
 Nov 4;35(44):14794-808. doi: 10.1523/JNEUROSCI.1295-15.2015.

5. Jong-Hyun Son, Ursula H. Winzer-Serhan (2015) In Situ Hybridization Methods, Neuromethods Vol99. In Giselbert Hauptmann (ed.), Combined radioactive and non-radioactive double in situ hybridization (DISH)(PP320-338). New York: Springer Science+Business Media.
6. Jong-Hyun Son, James Kuhn, and Kristen A. Keefe (2013) Perseverative behavior in rats with methamphetamine-induced neurotoxicity. Neuropharmacology, 67:95-103.
7. Jong-Hyun Son, Christine Latimer, Kristen A. Keefe (2011) Impaired formation of stimulus-response, but not action-outcome, associations in rats with partial striatal dopamine loss induced by methamphetamine.Neuropsychopharmacology, 36(12): 2441-2451.
8. Jong-Hyun Son, Ursula H. Winzer-Serhan (2009) Chronic neonatal nicotine exposure increases expression of neurotrophic factors in the postnatal rat hippocampus. Brain Research, 1278: 1-14.
9. Jong-Hyun Son, Ursula H. Winzer-Serhan (2009) Signal intensities of radiolabeled cRNA probes used alone or in combination with non-isotopic in situ hybridization histochemistry. Journal of Neuroscience Methods, 179(2): 159-165.
10. Jong-Hyun Son, Ursula H. Winzer-Serhan (2008) Expression of neuronal nicotinic acetylcholine receptor subunit mRNAs in rat hippocampal GABAergic interneurons. Journal of Comparative Neurology, 511:286-299.
11. Jong-Hyun Son, Ursula H. Winzer-Serhan (2006) Postnatal expression of alpha2 nicotinic acetylcholine receptor subunit mRNAs in developing cortex and hippocampus. Journal of Chemical Neuroanatomy, 32:179-190
.
INVITED PRESENTATIONS :
Scranton Neuroscience Society, University of Scranton, “Dynamic in vivo monitoring of synaptic formation in the developing zebrafish brain”, September 28, 2017
POSTER PRESENTATIONS:
Tyler M. Bielinski, Jake N. MacDonald, Matthew R. Barrett, Marc Seid, Joshua Bonkowsky, Jong-Hyun Son (2018) Differing effects of hypoxia on diencephalic dopaminergic neurons in the developing zebrafish brain. Society for Neuroscience

RESEARCH MENTORING:
Angelica Tulley, undergraduate research assistant, University of Scranton, 2018 – Independent research project
Tyler Bielinski, undergraduate research assistant, University of Scranton, 2018
Jake MacDonald, undergraduate research assistant, University of Scranton, 2018
Ethan Mulrooney, undergraduate research assistant, University of Scranton, 2018
Nolan McLaughlin, undergraduate research assistant, University of Scranton, 2018
Maxwell Greene, undergraduate research assistant, University of Scranton, 2018
GRANT SUBMISSION :
1. Faculty research development – Internal research grants 2017
2. 2018-2019 Strategic Initiatives funding plan
3. Whitehall Foundation, Grants-In-Aid, 2018
4. Increased Risk for Psychostimulant Abuse by Developmental Hypoxia. KO1 NIDA (Feb 5th2015)
5. Impaired response inhibitory control induced by methamphetamine neurotoxicity. RO1 NIDA (Oct 5th2012)
PUBLIC SERVICES:
1. Student outreach program to McNichols Plaza, May 10, 2018
2. Student outreach program to McNichols Plaza, March 22, 2018
3. Granite School District Science Fair Judge (7th-9thgrade), 2011-2012
4. Brain Awareness Weeks, a Campaign volunteer, 2010-2011, 2015
POST-HOC REVIEWS:
1. Development, 2014

2. Neuroscience Letters, 2012

 

Contact

 
Address
#372, Biology Dept. 
Loyola Science Center 
The University of Scranton
Scranton, PA 18510-4699
Phone
570) 941-6216
Fax
570) 941-7572
Email
jong-hyun.son@scranton.edu